Tuesday, September 13, 2011

Painkillers is linked to Miscarriage Risk

Some recent studies have shown that the use of certain painkiller can increase the risk of miscarriage. Women, who are taking non-steroidal anti-inflammatory drugs (NSAIDs) during their first 20 weeks of pregnancy, have increased the chances of losing baby. NSAIDs include popular painkillers like naproxen and ibuprofen. Generally, they are used to treat muscle injuries, headaches, and menstrual cramps.

Painkillers Linked to Miscarriage Risk
Image source: news.sciencemag.org
As per report published in the Canadian Medical Association Journal, the risk of miscarriage is 2.4 times bigger for women who take painkillers are harmful. The study included more than 52,000 pregnant women. It found that miscarriage rates were double among those who got one prescription for a non-steroidal anti-inflammatory drug compared to women who didn’t get that prescription.

The Canadian Medical Association Journal does not prove that NSAIDs only caused some women’s miscarriages. But this could very well be a pharmacological effect. Researchers have found that 7.5% had prescription out of 4,705 women who had a miscarriage during pregnancy. There are also other reasons for miscarriages that consist of underlying medical conditions such as rheumatoid arthritis (RA) and lupus.

Anick Berard, an epidemiologist and professor of pharmacy at the University of Montreal says, during early pregnancy women used NSAIDs for four days that was enough to increase risk. She also says that during first trimester, women should think about safest alternatives and should plan their pregnancy so that they can lower the risk of miscarriages.

Women used Celebrex and ibuprofen have more than double risk and those who are taking vioxx, had a greater risk that is 83% which is no longer sold in the U.S. Miscarriages also happen due to other health problem like depression, diabetes, lupus, rheumatoid arthritis, and untreated thyroid disease.

Limitation of the study:
  • Prescription for NSAID doesn’t mean that patients take the drugs.
  • Even though It had been shown that, the use of non-aspirin NSAIDs during pregnancy increase the risk of congenital malformations, up to 17 percent of pregnant women take the drugs either available over - the - counter or by prescription.
  • The painkiller ibuprofen and naproxen are more hazardous during pregnancy which are available over the counter in Canada (as it is in the U.S.).
  • As per study, the miscarriage groups also had higher rates of depression and nervousness.
Women Who Miscarry More Than Twice As Likely To Have Taken Certain Painkillers Video from youtube:


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